This book provides the essential tools to make the transition from digital business to autonomic business. A key defining feature of the autonomic business model is the emergence of AI agents as the primary drivers of automation within organizations, enabling systems to act autonomously, adaptively, and intelligently. As this model gains traction, practitioners and executives must understand both the opportunities and challenges that agentic AI presents to their enterprises. With the rapid pace of technology, it is becoming increasingly difficult to interpret what AI means in a business context and anticipate the unprecedented changes this AI wave will bring. This book offers insights into that future and outlines the steps organizations can take today to embark on their AI transformation journey. Drawing on real-world examples, the book examines the historical and theoretical foundations of AI agents and autonomic business, explores key aspects of an autonomic transformation, and the future of autonomic business. It appeals to a broad audience across business and technology sectors, including executive professionals, consultants, and students.