This extensive volume explores the phenomena of chaotic genomic rearrangements, known as chromoanagenesis, their formation mechanisms, and the state-of-the-art techniques used to detect them. The book delves into the potential impact of chromoanagenesis on cancers and congenital diseases, as well as its broader implications for genomic evolution and human health through a variety of cutting-edge methodologies. Written for the highly successful Methods in Molecular Biology series, most chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls.  Authoritative and comprehensive, Chromoanagenesis: Methods and Protocols serves as an ideal guide to the mechanisms and consequences of chromoanagenesis and a resource for researchers and clinicians seeking to explore the cutting-edge techniques and models used to study this phenomenon.