The purpose of the book is to focus attention and offer suggestions on controversial and challenging topics in allogeneic stem cell transplant. Over 40,000 allogeneic hematopoietic cell transplants (HCT) are done worldwide each year. Despite advances in allogeneic transplant, the cure rate is only 50-70%, depending on disease and patient factors. The book focuses on key topics such as patient selection, donor selection, conditioning regimens, graft vs. host disease prophylaxis regimens, maintenance strategies, and other topics that affect patient outcomes. The authors also discuss access to transplant care. Through dissemination of these topics, we hope to educate health care professionals caring for these patients, and improve patient outcomes. This is an essential resource for transplant physicians, hematologists/oncologists, and advance practice providers. Several of the topics are controversial issues that are discussed “round the table” frequently by transplant teams.