Focusing on a front line treatment for posttraumatic stress disorder (PTSD) and related problems, this book bridges science and practice to provide clinicians with an important tool for use across populations and settings. It is a detailed, yet digestible, review of the literature supporting the use of Cognitive Processing Therapy (CPT) followed by relevant clinical implications for evidence-based practice. Clear connections are made between case conceptualization and actual treatment. Chapters include case examples with client-therapist dialogue to provide practical guidance for clinicians delivering CPT with each patient population. Additionally, guidance for implementing CPT in alternative treatment formats (e.g., group treatment, intensive delivery modalities, and telehealth) and advice for navigating systemic barriers and disseminating CPT across different healthcare settings are included. Each chapter, written by a leading expert in each topic area, ensures that this book provides a comprehensive guide to enhance clinicians’ knowledge and skill in CPT treatment delivery across a wide range of complex patient populations, presentations, and treatment settings.