Structural heart disease encompasses a wide range of abnormalities involving noncoronary structures like the heart's valves, walls, and chambers. The last decade emphasized the burden of the disease and revolutionized the treatment strategies. The number of percutaneous structural heart interventions constantly increases worldwide. While some parts of the world acquire experience with various intervention treatments, techniques, and devices, others are paving their first steps. Complex Cases in Structural Heart Interventions provide a descriptive and highly illustrative insight into unique clinical situations managed by one of the world's most experienced and innovative teams. Each case study contains a clinical presentation, imaging analysis, procedural dilemmas, and resulting outcome. A detailed explanation of the technique used, key points and tips were highlighted, and a literature review covered broad knowledge on each topic. The authors shared their knowledge and distinctive solutions from over a decade of experience to ensure an educational adventure for the medical community and a roadmap for interventional heart teams.