This volume LNCS 15276 constitutes the revised selected papers of the 19th International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics, CIBB 2024, held in Benevento, Italy, during September 4–6, 2024. The 24 full papers and 3 short papers were carefully reviewed and selected from 28 submissions. They were organized in the following topical sections: Bioinformatics; Medical Informatics; Natural Language Processing (NLP) and Large Language Models (LLM) for Unstructured Data in Health Informatics; Modeling and Simulation Methods for Computational Biology and Systems Medicine; Machine Learning for Structured Data in Clinical Informatics and Medical Biology; Computational Intelligence in Personalized Medicine; and Computational Structural Bioinformatics.