This three part LNCS volumes constitutes the refereed proceedings of the 19th International Conference on Computer-Aided Systems Theory, EUROCAST 2024, held in Las Palmas de Gran Canaria, Spain, during February 25 to March 1, 2024. The 104 full papers included in this book were carefully reviewed and selected from 150 submissions. They were organized in topical sections as follows :Part I :  Systems Theory, Applications, Pioneers, and Landmarks; Theory and Applications of Metaheuristic Algorithms; Mechatronic Product Development; and Model-Based System Design, Verification and Simulation. Part II :  Applications of Signal Processing Technology; Applied Data Science and Engineering for Intelligent Transportation Systems and Smart Mobility; Computer and Systems Based Methods and Electronic Tools in Clinical and Academic Medicine ; Systems in Industrial Robotics, Automation and IoT; Systems Thinking: Applications in Technology, Science and Management; and Data Science in Medical and Bio-Informatics. Part III : Modeling, Simulation, and Optimization in Production and Logistics; "Green AI" and SW-Tools for Sustainable Energy and Materials Consumption; Stochastic Models, Statistical Methods, and Applied Systems Simulations; and Systems Cybersecurity Technologies and Quantum Approaches Potentials.