This book presents the evolution of the electro-discharge machining (EDM) process from conventional EDM to powder mixed EDM with emphases on biomedical applications. It discusses the theory behind each process and their applications in the field of biomedical research, and presents a brief background to various EDM processes, current research challenges, and detailed case studies of powder mixed EDM of various materials. It also includes a state-of-the-art review of the EDM process. Features:Focuses on biomedical implant and device manufacturing using commercialization of powder mixed electro-discharge machining (PM-EDM) technologyDiscusses surface modification of biomaterials through the PM-EDM processReviews processing of the metallic biomaterials for biomedical applicationsExplores optimization of the process factors for achieving optimal responses using NSGA-IIIncludes comprehensive mechanism and application details of the PM-EDM processThis book is aimed at graduate students and researchers in manufacturing, production, materials, and biomedical engineering.