This book introduces a cross-layer design to achieve security and resilience for CPSs (Cyber-Physical Systems). The authors interconnect various technical tools and methods to capture the different properties between cyber and physical layers. Part II of this book bridges the gap between cryptography and control-theoretic tools. It develops a bespoke crypto-control framework to address security and resiliency in control and estimation problems where the outsourcing of computations is possible. Part III of this book bridges the gap between game theory and control theory and develops interdependent impact-aware security defense strategies and cyber-aware resilient control strategies. With the rapid development of smart cities, there is a growing need to integrate the physical systems, ranging from large-scale infrastructures to small embedded systems, with networked communications. The integration of the physical and cyber systems forms Cyber-Physical Systems (CPSs), enabling the use of digital information and control technologies to improve the monitoring, operation, and planning of the systems. Despite these advantages, they are vulnerable to cyber-physical attacks, which aim to damage the physical layer through the cyber network. This book also uses case studies from autonomous systems, communication-based train control systems, cyber manufacturing, and robotic systems to illustrate the proposed methodologies.  These case studies aim to motivate readers to adopt a cross-layer system perspective toward security and resilience issues of large and complex systems and develop domain-specific solutions to address CPS challenges. A comprehensive suite of solutions to a broad range of technical challenges in secure and resilient control systems are described in this book (many of the findings in this book are useful to anyone working in cybersecurity). Researchers, professors, and advanced-level students working in computer science and engineering will find this book useful as a reference or secondary text. Industry professionals and military workers interested in cybersecurity will also want to purchase this book.