This volume constitutes the refereed proceedings of the workshops held at the 33rd International Conference on Database and Expert Systems Applications, DEXA 2022, held in Vienna, Austria, in August 2022: The 6th International Workshop on Cyber-Security and Functional Safety in Cyber-Physical Systems (IWCFS 2022)

4th International Workshop on Machine Learning and Knowledge Graphs (MLKgraphs 2022)

2nd International Workshop on Time Ordered Data (ProTime2022)

2nd International Workshop on AI System Engineering: Math, Modelling and Software (AISys2022)

1st International Workshop on Distributed Ledgers and Related Technologies (DLRT2022)

1st International Workshop on Applied Research, Technology Transfer and Knowledge Exchange in Software and Data Science (ARTE2022).  The 40 papers were thoroughly reviewed and selected from 62 submissions, and discuss a range of topics including: knowledge discovery, biological data, cyber security, cyber-physical system, machine learning, knowledge graphs, information retriever, data base, and artificial intelligence.