This book constitutes the refereed proceedings of the 10th International Symposium on Dependable Software Engineering. Theories, Tools, and Applications, SETTA 2024, held in Hong Kong, China, during November 26–28, 2024. The 21 full papers included in this book were carefully reviewed and selected from 47 submissions. The purpose of the SETTA symposium series is to bring international researchers together to exchange research results and ideas on bridging the gap between formal methods and software engineering.