This book constitutes the refereed proceedings of the Third International Conference on Design, Operation and Evaluation of Mobile Communications, MOBILE 2022, held as part of the 23rd International Conference, HCI International 2022, which was held virtually in June/July 2022. The total of 1271 papers and 275 posters included in the HCII 2022 proceedings was carefully reviewed and selected from 5487 submissions. The MOBILE 2022 proceedings were organized in the following topical sections: Designing Mobile Interactions and Systems; User Experience and Adoption of Mobile Communications; Mobile Commerce and Advertising; Mobile Interactions with Agents; Emerging Mobile Technologies.