This book is a clinically focused guide for the evaluation and management of pancreatic cystic lesions, integrating advances in endoscopic ultrasound (EUS), cross-sectional imaging, cytology, and cyst fluid analysis to improve diagnostic accuracy. It discusses the diagnostic and therapeutic challenges associated with these lesions and supports effective clinical decision-making. The chapters provide detailed insights into pancreatic cystic lesions, with clear discussions on cytology, fluid tumor markers, and molecular profiling to enhance diagnostic precision. The book also addresses evidence-based surgical and non-surgical management strategies, enabling confident, real-world decision-making. It is supplemented with high-quality images from contrast-enhanced computed tomography (CECT), magnetic resonance imaging (MRI), EUS, as well as cytological and histopathological findings, to aid clinical interpretation. This book is relevant for practitioners in gastroenterology, pancreatic surgery, radiology, and pathology, as well as researchers seeking a clinically relevant understanding of pancreatic cystic lesions.