This book presents the proceedings of the 2019 International Conference on Digital Science (DSIC 2019), held in Limassol, Cyprus, on October 11–13, 2019.  DSIC 2019 was an international forum for researchers and practitioners to present and discuss the most recent innovations, trends, results, experiences and concerns in digital science. The main goal of the conference was to efficiently disseminate original findings in the natural and social sciences, art & the humanities. The contributions in the book address the following topics: Digital Art & HumanitiesDigital EconomicsDigital EducationDigital EngineeringDigital Finance, Business & BankingDigital Healthcare, Hospitals & RehabilitationDigital MediaDigital Medicine, Pharma & Public HealthDigital Public AdministrationDigital Technology & Applied SciencesDigital VirtualReality