This book is intended for medical and mental health clinicians faced with the challenge of evaluating adolescents and adults in the legal context who may have a fetal alcohol spectrum disorder (FASD). Luminaries in their respective fields, the contributors to this book offer a range of expertise and perspectives regarding the forensic investigation of FASD: medical, psychological, psychiatric, criminal defense, prosecution, and the judiciary. The primary goal of the book is to provide medical and mental health clinicians with practical procedures that can be used in a variety of forensic and clinical settings. It includes protocols that have been used successfully in legal matters ranging from rights waiver and competency to capital murder and sexual offending. It not only provides detailed guidelines for interviewing birth mothers about the delicate topic of substance use during pregnancy but also introduces a methodology that can be usedin the absence of exposure confirmation to arrive at a sound diagnostic conclusion through the process of differential diagnosis. Taken as a whole, the methodological procedures described by the contributors to the book serve as ‘best practices’ for comprehensive forensic mental health evaluation of potential FASD in juveniles and adult defendants as well as in victims.