This book constitutes the refereed proceedings of the 22nd European Conference on Evolutionary Computation in Combinatorial Optimization, EvoCOP 2022, held as part of Evo*2022, in Madrid, Spain, during April 20-21, 2022, co-located with the Evo*2022 events: EvoMUSART, EvoApplications, and EuroGP. The 13 revised full papers presented in this book were carefully reviewed and selected from 28 submissions. They present recent theoretical and experimental advances in combinatorial optimization, evolutionary algorithms, and related research fields.