This book highlights recent progress in artificial intelligence applied to the design of intelligent, adaptive, and efficient systems. It presents advanced methods in machine learning, optimisation, modelling, and software engineering, showing how AI-driven approaches improve reliability and support informed decision-making across diverse domains. As part of the Computational Methods in Systems and Software 2025 conference, titled “Focus on Artificial Intelligence in Intelligent Systems Design,” this collection brings together contributions that connect theory with real-world applications in industry, economics, and organisational processes. The book illustrates emerging trends shaping the next generation of computational and intelligent systems. This book serves researchers, practitioners, and students seeking concise insights into modern AI-enhanced methods and their practical impact.