Computational fluid-structure interaction (FSI) and flow simulation are challenging research areas that bring solution and analysis to many classes of problems in science, engineering, and technology. Young investigators under the age of 40 are conducting much of the frontier research in these areas, some of which is highlighted in this volume. The first author of each chapter took the lead role in carrying out the research presented. Some of the topics explored includeDirect flow simulation of objects represented by point cloudsComputational investigation of leaflet flutter in thinner biological heart valve tissuesHigh-fidelity simulation of hydrokinetic energy applicationsHigh-resolution isogeometric analysis of car and tire aerodynamicsComputational analysis of air-blast-structure interactionHeart valve computational flow analysis with boundary layer and leaflet contact representationComputational thermalmulti-phase flow for metal additive manufacturingThis volume will be a valuable resource for early-career researchers and students — not only those interested in computational FSI and flow simulation, but also other fields of engineering and science, including fluid mechanics, solid mechanics, and computational mathematics – as it will provide them with inspiration and guidance for conducting their own successful research. It will also be of interest to senior researchers looking to learn more about successful research led by those under 40 and possibly offer collaboration to these researchers.