This edited book provides some future perspectives on Human-Computer Interaction research and serves as a crucial nexus for reflecting on the paths that have led us here. Technologies are increasingly becoming active agents capable of learning, adapting, and making decisions. The classic User-Centred Design approach that positions the user strictly at the centre may no longer suffice. Putting the human-in-the-loop are crucial elements for trusting AI technologies and building better, more human-centred, ones.  Offering a comprehensive overview of current research and future directions in this field it addresses important topics such as Human-Centred Artificial Intelligence, Augmented and Virtual Reality, User-Centred Design, and Children-Computer Interaction, providing insights into how these areas will continue to influence and transform our interaction with technologies. The chapters are enriched with case studies and examples that illustrate the practical application of methodological approaches and ideas.