In this issue of Obstetrics and Gynecology Clinics of North America, Dr. Cecile A. Ferrando brings her considerable expertise to the topic of Gender-Affirming Care. Top experts address how clinicians can stay informed about gender-affirming hormone therapy and its impact on gynecologic health; implement inclusive screening protocols that balance clinical guidelines with patient comfort and gender identity; offer fertility counseling and discuss reproductive options before starting hormone therapy; create a welcoming clinical environment; and collaborate with multidisciplinary teams (endocrinologists, urologists, mental health providers) to provide holistic care for gender-diverse patients. Contains 12 relevant, practice-oriented topics including a primer on gender diversity and the health care needs of transgender people; gender affirming medical treatment for transitioning patients; perioperative considerations for gender-affirming hysterectomy; updates on breast cancer screening and special considerations for transgender men and women; evaluation and management of the pediatric gender-diverse patient; and moreProvides in-depth clinical reviews on gender-affirming care, offering actionable insights for clinical practicePresents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews