A decade ago, Graphic Medicine Manifesto established a bold new framework for understanding the intersection of comics and healthcare. It was a call to action—an invitation to rethink the ways we engage with medicine, illness, disability, and caregiving through the power of visual storytelling. Now, ten years later, this landmark volume returns in a special anniversary edition that expands and reimagines its mission for a new era. With a new critical preface, this tenth-anniversary edition reflects on Graphic Medicine Manifesto’s legacy and its impact on healthcare, scholarship, and comics. It reaffirms the power of comics to challenge disciplines, amplify marginalized voices, and transform teaching in a range of health fields. Organized into six sections, the introduction explores the manifesto’s origins and ongoing relevance, its role as a radical tool in comics, the power of storytelling in health education, the expanding influence of graphic medicine on disability studies and the humanities, the importance of community and collaboration in breaking disciplinary silos, and the future of the field.  Featuring these newly contextualized insights alongside the original essays and visual narratives by Ian Williams, MK Czerwiec, and other leading practitioners, this new edition reaffirms Graphic Medicine Manifesto as an essential text for scholars, healthcare professionals, creators, and anyone engaging with medicine, illness, and caregiving through the power of comics.