This book constitutes the refereed proceedings of the 37th International Conference on High Performance Computing, ISC High Performance 2022, held in Hamburg, Germany, during May 29 – June 2, 2022. The 18 full papers presented were carefully reviewed and selected from 53 submissions. The papers are categorized into the following topical sub-headings: Architecture, Networks, and Storage; Machine Learning, AI, Emerging Technologies; HPC Algorithms and Applications; Performance Modeling, Evaluation and Analysis; and Programming Environments and Systems Software.