This book constitutes the refereed proceedings of the 7th International Conference on Information and Knowledge Systems, ICIKS 2025, held in Sousse, Tunisia, during October 2025. The 19 full papers and 1 short paper included in this book were carefully reviewed and selected from 55 submissions. They were organized in topical sections as follows: Artificial Intelligence and Data-Driven Modelling; Intelligent Information Systems and Digital Environments; and Knowledge Representation and Language Technologies.