This book constitutes the refereed proceedings of the 25th International Conference on Integer Programming and Combinatorial Optimization, IPCO 2024, held in Wroclaw, Poland, during July 3–5, 2024. The 33 full papers presented were carefully reviewed and selected from 101 submissions. IPCO is under the auspices of the Mathematical Optimization Society, and it is an important forum for presenting present recent developments in theory, computation, and applications. The scope of IPCO is viewed in a broad sense, to include algorithmic and structural results in integer programming and combinatorial optimization as well as revealing computational studies and novel applications of discrete optimization to practical problems.