Research into plant-based antifungals offers a viable alternative to discover potent, eco-friendly, and sustainable treatments. Natural antifungal compounds offer a promising solution, as they tend to have fewer side effects and reduced risk of resistance development compared to synthetic alternatives.This Set delves into the application of metagenomics in identifying and harnessing the microbial communities associated with medicinal plants. By integrating bioprospecting techniques with cutting-edge genomic technologies, this work opens up promising new avenues to provide insights into the potential of natural products for developing novel antifungal therapies.