This book collects 43 regular papers received from 18 countries that present innovative advances in intelligent and distributed computing, encompassing both architectural and algorithmic results related to these fields. Significant attention is given to new models, techniques, and applications for distributed intelligent architectures and high-performance architectures, machine learning techniques, Internet of Things, blockchain, intelligent transport systems, data analytics, trust and reputation systems, and many others. The book includes the peer-reviewed proceedings of the 14th International Symposium on Intelligent Distributed Computing (IDC 2021), which was held in online mode due to the COVSARS2 pandemic situation, during September 16–18, 2021. The IDC 2021 event included sessions on Internet of Things, data analytics, machine learning, multi-agent systems, algorithms, future intelligent transport solutions, blockchain, intelligent distributed computing for cyber-physical security, and security and trust and reputation in intelligent environments.