This two-volume set CCIS 2858-2859 constitutes the refereed proceedings of the 5th International Conference on Intelligent Systems and Pattern Recognition, ISPR 2025, held in Hammamet, Tunisia, during September 25–27, 2025. The 59 full papers presented in these volumes were carefully reviewed and selected from the 180 submissions. They over a wide spectrum of contemporary research topics, including machine learning, deep learning, computer vision, data mining, intelligent systems, explainable artificial intelligence, pattern recognition methodologies, and multimedia analysis.