This book LNICST 621 constitutes the proceedings of the First EAI International Conference on Intelligent Systems with Applications in Communications, Computing and IoT, ICISCCI 2024, held in Hyderabad, India, during August 23–24, 2024. The 39 full papers were carefully reviewed and selected from 97 submissions. The proceedings focuses on the topics such as 1) Intelligent systems and Machine Learning Applications2) Intelligent Systems with Applications in Communication Networks 3) Intelligent Systems in IoT