This book features a selection of the best papers accepted for presentation and discussion at the 2025 International Conference in Information Systems and Medicine (ICISMED25). Held from April 3 to 5, 2025, ICISMED25 is a multidisciplinary conference with a particular focus on emerging technologies and systems in the healthcare sector. The event was supported by the Universidad Autónoma de Chile in Santiago and the International Association for Digital Transformation and Technological Innovation (IADITI). This volume is intended for researchers, academics, lecturers, specialists, professionals, doctoral and master's students, undergraduates, and practitioners working at the intersection of healthcare and information technologies. The book addresses foundational and advanced concepts related to the paradigm of intelligent computing and communication within the context of distributed computing, big data, high-performance computing, and the Internet of Things (IoT), specifically applied to health care. Given the critical need to develop adaptive, intelligent, energy-efficient, secure, and privacy-aware mechanisms in high-performance and IoT-based healthcare applications, this book serves as both a practical reference for industry professionals and a foundational guide for beginners. It facilitates understanding from basic principles to advanced practices in computing paradigms and their application to healthcare challenges. Global health research increasingly prioritizes responsive strategies to the rapid changes reshaping our world—technological, political, social, cultural, educational, and economic—all of which impact healthcare delivery and systems. This publication provides an opportunity for academics and practitioners from diverse health-related fields to build bridges of knowledge, encourage research, and support the ongoing evolution of healthcare systems. The ICISMED25 Scientific Committee comprises a multidisciplinary panel of 120 experts who reviewed 94 submissions from 17 countries.