This book provides readers with a timely snapshot of modeling and simulation tools, including virtual and mixed-reality environment, for human factors research. It covers applications in healthcare and physical ergonomics, military and transportation systems, industrial monitoring, as well as economics and social sciences. Based on the AHFE 2021 International Conference on Human Factors and Simulation and the AHFE 2021 International Conference on Digital Human Modeling and Applied Optimization, held virtually on 25–29 July, 2021, from USA, the book offers a unique resource for modelling and simulation researchers seeking insights into human factors research and to human factors experts seeking reliable computational tools.