This book constitutes the refereed post-conference proceedings of the Second IFIP International Cross-Domain Conference on Internet of Things, IFIPIoT 2019, held in Tampa, USA, in October/ November 2019. The 11 full papers presented were carefully reviewed and selected from 22 submissions. Also included in this volume are 8 invited papers. The papers are organized in the following topical sections: IoT applications; context reasoning and situational awareness; IoT security; smart and low power IoT; smart network architectures; and smart system design and IoT education.