The focus of this book is on profiling, analysing, benchmarking, and modeling in socio-technical terms, ways and means that creativity, invention and innovation are manifested and flourish in select American, European, and Asian knowledge-based innovation networks and knowledge clusters. This book will present a number of conceptual and emperical studies from the USA, Europe and Asia, that contribute to a better understanding of the role of knowledge in the theory and practice of technological entrepreneurship in the context of socio-technical networks, architecture design, form and function and from other diverse theoretical perspectives.