Large Systems Change (LSC) is a field of study and action that is characterized by its focus on transformational pathways towards a participative, flourishing future through inter- and trans-disciplinary approaches that value engagement with practitioners and those aspiring for such futures.  Its emergence holds great promise for addressing critical issues.  Advancing its development requires aggressiveness to cross the many disciplinary, institutional and other boundaries and build the necessary scale of effort;  however, humbleness is also required to recognize that although we have substantial knowledge and methodologies for approaching LSC, we are still at early stages of their development. The papers in this Special Issue of The Journal of Corporate Citizenship focus on the question of how to scale to the field of LSC. We can see the contributors and editors reflect on this at the three levels:  broadening by increasing the numbers of people and organizations identified with it; going up and out with a more receptive environment arising with failures of traditional management approaches; and deepening of knowledge and methods for supporting LSC. This Special Issue will be essential reading for those researching in this emerging field, and practitioners looking for the latest thinking on how LSC may be a solution to global challenges.