This book constitutes the thoroughly refereed post-conference proceedings of the 28th International Symposium on Logic-Based Program Synthesis and Transformation, LOPSTR 2018, held in Frankfurt/Main, Germany, in September 2018.The 11 revised full papers were carefully reviewed and selected from 29 submissions. In addition to the 11 papers, this volume includes 3 abstracts of invited talks and 2 abstracts of invited tutorials. The papers are grouped into the following topics: analysis of term rewriting; logic-based distributed/concurrent programming; analysis of logic programming; and program analysis.