This volume gathers selected, peer-reviewed papers presented at the Sixth Scientific Days of the Doctoral School of Mathematics and Computer Sciences (S2DSMCS), held from December 17–19, 2024, at Cheikh Anta Diop University in Dakar, Senegal. The works contained within showcase research activities developed by a new generation of mathematicians and computer scientists from Africa, Europe, Asia, and America. Covered topics focus on the theory and applications of cryptography, information security, and artificial intelligence, ranging from discrete algebra to specific implementations such as blockchain, machine learning algorithms, and the use of cutting-edge technologies in security contexts. By fostering cooperation among both young and experienced researchers, the S2DSMSC conference aligns with other conferences in the region, such as Africacrypt - the International Conference on Cryptology in Africa, the Non-commutative Algebra and Operator Theory (NANCAOT) international workshops, and the International Conference in Algebra, Codes, and Cryptology (A2C), all with proceedings published by Springer.