This second edition of the highly successful textbook Metabolism of Human Diseases expands on the role of key molecules in the human body and how their defective metabolism leads to common human diseases. This textbook integrates concepts from biochemistry, physiology and pathophysiology to provide a comprehensive overview of organ- and tissue-specific metabolism and signaling pathways that contribute to human diseases. The chapters focus on the metabolic processes of the main organs in the human highlighting on many diseases that are frequently diagnosed, have high mortality rates, and are costly to treat. As metabolic research continues to unveil critical insights into physiology and pathophysiology, this edition incorporates the latest findings to enhance our understanding of how defective metabolism and signaling pathways contribute to prevalent conditions such as Alzheimer's disease, depression, diabetes, food intolerance, heart failure, macular degeneration and cancer. Authored by over 100 international experts, it serves as a vital tool for anyone dedicated to understanding the complexities of human diseases through the lens of metabolism.  It not only provides a comprehensive resource on the metabolic mechanisms of diseases but also presents therapeutic strategies to combat them. Ideal for graduate students, postdocs, and scientists in metabolic research, biochemistry, and physiology, as well as physicians interested in molecular mechanisms of human physiology and disease.