Chapter 1. Introduction to multi-omics.- Part 1. Omics integration techniques.- Chapter 2. Biomedical applications: the need for multi-omics.- Chapter 3. Omics technologies and big data.- Chapter 4. Multi-omics data mining techniques: algorithms and software.- Part 2. Applications of multi-omics analyses.- Chapter 5. Multi-omics data analysis for cancer research: colorectal cancer, liver cancer and lung cancer.- Chapter 6. Multi-omics data analysis for inflammation disease research: correlation analysis, causal analysis and network analysis.- Chapter 7. Microbiome data analysis and interpretation: correlation inferences and dynamic pattern discovery.- Chapter 8. Current progress of bioinformatics for human health.