Developed as a one-stop reference source for drug safety and toxicology professionals, this book explains why mitochondrial failure is a crucial step in drug toxicity and how it can be avoided. •    Covers both basic science and applied technology / methods•    Allows readers to understand the basis of mitochondrial function, the preclinical assessments used, and what they reveal about drug effects•    Contains both in vitro and in vivo methods for analysis, including practical screening approaches for drug discovery and development•    Adds coverage about mitochondrial toxicity underlying organ injury, clinical reports on drug classes, and discussion of environmental toxicants affecting mitochondria