In this issue of Infectious Disease Clinics of North America, guest editor Dr. Laura Certain brings her considerable expertise to the topic of Musculoskeletal Infections. Top experts present current data on how best to diagnose and manage diabetic foot infections, periprosthetic joint infections, vertebral osteomyelitis, infection after fracture fixation, and more. Notably, in many cases the optimal treatment approach remains unclear; in those cases, authors present what data is available, and how experts in orthopedic infections typically proceed. In addition, surgical colleagues provide a brief overview of considerations for surgical management of these infections. Contains 13 relevant, practice-oriented topics including jaw osteomyelitis; preventing orthopedic infections; interdisciplinary care for patients with musculoskeletal infections; local antibiotic therapy for musculoskeletal infections; infection after sarcoma surgery; and moreProvides in-depth clinical reviews on musculoskeletal infections, offering actionable insights for clinical practicePresents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews