1. Clinical presentation of myeloma bone disease (MBD) 2. Imaging of myeloma bone disease 3. Bone Markers in MBD 4. Radiation therapy for MBD5. Surgical treatment (kyphoplasty, vertebroplasty and standard surgery) 6. Pathophysiology of MBD7. Osteoclast activation in MBD8. Osteoblast Suppression in MBD9. Animal models of MBD10. Bisphopsphonate treatment of MBD11. Osteonecrosis of the jaw in myeloma12. Novel therapies for MBD (Denosumab, velcade and imids)