This book is an introduction to a comprehensive analysis of recent advances and clinical research in noninvasive mechanical ventilation (NIV) in Pulmonary, Critical Care, and Sleep Medicine. The objective of the book is to increase the knowledge and understanding of the reader in the best clinical practice in three main sections. A selected international group of experts in the field of noninvasive ventilation formed a panel to provide an update on the recent literature in the application and efficient utilization of NIV in Pulmonary, Critical Care, and Sleep Medicine. Each particular section will discuss the application of NIV in different disease process. The authors summarized the main results of the recent trials, clinical and technological advances, expert opinions, and practical guidelines. Chapters, summarized by expert committee, provide a “deep and exhaustive critical analysis and summary” of the recent advances in the field of NIV, presented as key points and/recommendations for the best clinical practice from articles published in the last decade. The content of the book will serve as a resource and a tool to the practicing physicians toward NIV. Main objective is to increase their proficiency in management of different pathophysiological aspects of the respiratory system. In this line, the book offers to the readers, who are seeking the latest recommendations, the future research directions in noninvasive mechanical ventilation. Table of contents describe and analyze, the items trend setters in noninvasive ventilation, organized in three main sections, “pulmonary”, “critical care” and “sleep medicine”, using the primary keyword related with term “noninvasive mechanical ventilation” as search term associated with “secondary keywords” studies from a period of 2018 to 2019. This searching methodology and analysis define this unique book to the approach in noninvasive mechanical ventilation for best clinical practice, research, clinical study designs and critical analysis, how noninvasive ventilation is current and trending. Based on this form of conception of book updated, editors and authors consider that this book opens a new and original vision for adequate knowledge and deep updated based on key publications in the period under review, very useful for clinical practice, studies designs and potential new trends in the use of noninvasive ventilation. As such, it is a unique update book resource in noninvasive ventilation in pulmonary, critical care and sleep medicine that may influence current clinical practice and future studies. With ultimate goal is better care and outcome for our patients.