This book gathers peer-reviewed, selected contributions from participants of the 6th International Workshop on Nonlinear and Modern Mathematical Physics (NMMP-2022), hosted virtually from June 17–19, 2022. Works contained in this volume cover topics like nonlinear differential equations, integrable systems, Hamiltonian systems, inverse scattering transform, Painleve's analysis, nonlinear wave phenomena and applications, numerical methods of nonlinear wave equations, quantum integrable systems, and more. In this book, researchers and graduate students in mathematics and related areas will find new methods and tools that only recently have been developed to solve nonlinear problems. The sixth edition of the NMMP workshop was organized by Florida A&M University in Tallahassee, Florida, USA, with support from the University of South Florida, Florida State University, Embry-Riddle Aeronautical University, Savannah State University, Prairie View A&M University, and Beijing Jiaotong University. The aim was to bring together researchers from around the world to present their findings and foster collaboration for future research.