Establishing a well-defined, well-organized and clear regulatory review and assessment process at each licensing step is key to achieving the highest level of safety throughout the lifetime of a nuclear power plant. Reflecting a project management approach adopted in many States, this publication provides practical guidance for the planning, management and conduct of the review and assessment by regulatory bodies of applications for authorization. It is intended for the managers and staff of regulatory bodies of States, particularly those embarking on a nuclear power programme, who are involved in the regulatory review and assessment process.