This multi-vocal assemblage of literary and cultural responses to contagions provides insights into the companionship of posthumanities, environmental humanities, and medical humanities to shed light on how we deal with complex issues like communicable diseases in contemporary times. Examining imaginary and real contagions, ranging from Jeep and SHEVA to plague, HIV/AIDS, and COVID-19, Posthuman Pathogenesis discusses the inextricable links between nature and culture, matter and meaning-making practices, and the human and the nonhuman. Dissecting pathogenic nonhuman bodies in their interactions with their human counterparts and the environment, the authors of this volume raise their diverse voices with two primary aims: to analyse how contagions trigger a drive to survival, and chaotic, liberating, and captivating impulses, and to focus on the viral interpolations in socio-political and environmental systems as a meeting point of science, technology, and fiction, blending social reality and myth. Following the premises of the post-qualitative turn and presenting a differentiated experience of contagion, this ‘rhizomatic’ compilation thus offers a non-hierarchised array of essays, composed of a multiplicity of genders, geographies, and generations.