This two-volume set LNCS 16528-16529 constitutes the refereed proceedings of the 28th Iberoamerican Congress on Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications, CIARP 2025, held in Bogotá, Colombia, during November 25–28, 2025. The 52 full papers included in these volumes were carefully reviewed and selected from 110 submissions. They cover a wide array of specialized topics, including but not limited to Artificial Intelligence, Biometrics, Cognitive and Humanoid Vision, Computer Vision, Deep Learning and Transfer Learning, Data Mining and Big Data, Natural Language Processing, Document Analysis, Image Processing and Analysis, Neural Networks, Remote Sensing Applications, and Statistical Pattern Recognition, alongside their transformative applications in industry, health, robotics, and telecommunications.