This monograph is intended for researchers and professionals in the fields of computer science and cybernetics. Nowadays, the areas of computer science and cybernetics (mainly its artificial intelligence branches) are subject to an immense degree of study and are applied in a wide range of technical and industrial projects. The individual chapters of this monograph were developed from a series of invited lectures at the Brno University of Technology in the years 2018 and 2019. The main aim of these lectures was to create an opportunity for students, academics, and professionals to exchange ideas, novel research methods, and new industrial applications in the fields related to soft computing and cybernetics. The authors of these chapters come from around the world and their works cover both new theoretical and application-oriented results from areas such as automation, control, robotics, optimization, statistics, reinforcement learning, image processing, and evolutionary algorithms.