This book constitutes the refereed proceedings of the First EAI International Conference on Safe, Secure, Ethical, Responsible Technologies and Emerging Applications, SAFER-TEA 2023, held in Yaoundé, Cameroon, during October 25-27, 2023.  The 24 full papers were carefully reviewed and selected from 75 submissions. They were organized in topical sections as follows: Regulations and Ethics of Artificial Intelligence, Resource-constrained Networks and Cybersecurity, Emerging Artificial Intelligence Applications, Reviews.