This book is a collection of research papers selected for presentation at the International Conference on Smart Computational Methods in Continuum Mechanics 2021, organized by Moscow Institute of Physics and Technology and the Institute for Computer Aided Design of Russian Academy of Sciences. The work is presented in two volumes. The primary objective of the book is to report the state-of-the-art on smart computational paradigms in continuum mechanics and explore the use of artificial intelligence paradigms such as neural nets and machine learning for improving the performance of the designed engineering systems. The book includes up-to-date smart computational methods which are used to solve problems in continuum mechanics, engineering, seismic prospecting, non-destructive testing, and so on. The main features of the book are the research papers on the application of novel smart methods including neural nets and machine learning, computational algorithms, smart software systems, and high-performance computer systems for solving complex engineering problems. The case studies pertaining to the real-world applications in the above fields are included. The book presents a collection of best research papers in English language from some of the world leaders in the field of smart system modelling and design of engineering systems.