Chapter 1: Introduction.- Chapter 2: Literature Review.- Chapter 3: Methodology.- Chapter 4: Study I. Hyperparameter optimization of neural network-driven spatial models accelerated using cyber-enabled high-performance computing.- Chapter 5: Study II. Spatially explicit hyperparameter optimization of neural networks accelerated using high-performance computing.- Chapter 6: Study III. An integration of spatially explicit hyperparameter optimization with convolutional neural networks-based spatial models.