This book details the foundations, new developments and methods, applications, and current challenges of systems engineering (SE). It provides key insights into SE as a concept and as an approach based on the holistic view on the entire lifecycle (requirements, design, production, and exploitation) of complex engineering systems, such as spacecraft, aircraft, power plants, and ships. Written by leading international experts, the book describes the achievements of the holistic, transdisciplinary approach of SE as state of the art both in research and practice using case study examples from originating at universities and companies such as Airbus, BAE Systems, BMW, Boeing, and COMAC. The reader obtains a comprehensive insight into the still existing challenges of the concept of SE today and the various forms in which SE is applied in a variety of areas.